ICOS co-stimulatory receptor is essential for T-cell activation and function.
In: Nature, Jg. 409 (2001-01-04), Heft 6816, S. 97-101
Online
academicJournal
Zugriff:
Shows that T-cell activation and proliferation are defective in the absence of inducible co-stimulatory molecule (ICOS). Generation and analysis of ICOS-deficient mice to understand the role of ICOS in T-cell activation; Failure of cells to produce interleukin-4 when differentiated in vitro or when primed in vivo; Indication that ICOS has a protective role in inflammatory autoimmune diseases.
Titel: |
ICOS co-stimulatory receptor is essential for T-cell activation and function.
|
---|---|
Autor/in / Beteiligte Person: | Dong, Chen ; Juedes, Amy E. ; Temann, Ulla-Angela ; Shresta, Sujan ; Allison, James P. ; Ruddle, Nancy H. ; Flavell, Richard A. |
Link: | |
Zeitschrift: | Nature, Jg. 409 (2001-01-04), Heft 6816, S. 97-101 |
Veröffentlichung: | 2001 |
Medientyp: | academicJournal |
ISSN: | 0028-0836 (print) |
DOI: | 10.1038/35051100 |
Schlagwort: |
|
Sonstiges: |
|