Machine learning models for diagnosis of essential tremor and dystonic tremor using grey matter morphological networks.
In: Parkinsonism & Related Disorders, Jg. 124 (2024-07-01), S. N.PAG
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Zugriff:
Essential tremor (ET) and dystonic tremor (DT) are the two most common tremor disorders, and misdiagnoses are very common due to similar tremor symptoms. In this study, we explore the structural network mechanisms of ET and DT using brain grey matter (GM) morphological networks and combine those with machine learning models. 3D-T1 structural images of 75 ET patients, 71 DT patients, and 79 healthy controls (HCs) were acquired. We used voxel-based morphometry to obtain GM images and constructed GM morphological networks based on the Kullback-Leibler divergence-based similarity (KLS) method. We used the GM volumes, morphological relations, and global topological properties of GM-KLS morphological networks as input features. We employed three classifiers to perform the classification tasks. Moreover, we conducted correlation analysis between discriminative features and clinical characteristics. 16 morphological relations features and 1 global topological metric were identified as the discriminative features, and mainly involved the cerebello-thalamo-cortical circuits and the basal ganglia area. The Random Forest (RF) classifier achieved the best classification performance in the three-classification task, achieving a mean accuracy (mACC) of 78.7%, and was subsequently used for binary classification tasks. Specifically, the RF classifier demonstrated strong classification performance in distinguishing ET vs. HCs, ET vs. DT, and DT vs. HCs, with mACCs of 83.0 %, 95.2 %, and 89.3 %, respectively. Correlation analysis demonstrated that four discriminative features were significantly associated with the clinical characteristics. This study offers new insights into the structural network mechanisms of ET and DT. It demonstrates the effectiveness of combining GM-KLS morphological networks with machine learning models in distinguishing between ET, DT, and HCs. • The findings showed that the ML algorithms achieved good classification performance in classification tasks, the most powerful 17 discriminative features mainly involved the cerebello-thalamo-cortical circuits and basal ganglia area. • RF classifier to perform the classification tasks had achieved good results, especially in identifying DT from ET and HCs. • A significant proportion of discriminative features (15/17, 88.2 %) consistently showed morphological relations between frontal lobe and other brain regions were deemed as the most vital in distinguishing ET, DT, and HCs. • Using SHAP analysis and bounding by a feature importance greater than 0.05, the involvement of the middle frontal gyrus, anterior cingulate and paracingulate gyri, and lingual gyrus were characteristic alterations of ET; the involvement of the SMA, vermis_4_5, and putamen were characteristic alterations of DT. [ABSTRACT FROM AUTHOR]
Titel: |
Machine learning models for diagnosis of essential tremor and dystonic tremor using grey matter morphological networks.
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Autor/in / Beteiligte Person: | Gui, Honge ; Xiao, Pan ; Xu, Bintao ; Zhao, Xiaole ; Wang, Hongyu ; Tao, Li ; Zhang, Xiaoyu ; Li, Qin ; Zhang, Xueyan ; Chen, Huiyue ; Wang, Hansheng ; Lv, Fajin ; Luo, Tianyou ; Cheng, Oumei ; Luo, Jin ; Man, Yun ; Xiao, Zheng ; Fang, Weidong |
Zeitschrift: | Parkinsonism & Related Disorders, Jg. 124 (2024-07-01), S. N.PAG |
Veröffentlichung: | 2024 |
Medientyp: | academicJournal |
ISSN: | 1353-8020 (print) |
DOI: | 10.1016/j.parkreldis.2024.106985 |
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