Prevencija progresije kronične bubrežne bolesti u 12 koraka.

This paper aims to provide a concise guide on how to successfully slow down chronic kidney disease (CKD) progression, with references to the latest evidence and recommendations. The Medline and Web of Science databases were used as the sources of medical literature, based on the combinations of keywords “chronic kidney disease”, “progression”, and “prevention”. The relevant original research papers and current national and international society guidelines were analyzed to extract recommendations and practice modifications for the optimal reduction of kidney disease progression. Regardless of etiology and type, there are certain interventions that have been proven to reduce the rate of CKD progression. Twelve of those will be examined and discussed herein: dietary intervention, anemia therapy, new mineralocorticoid receptor antagonists, inhibitors of sodium-glucose cotransporter-2, treatment of hyperuricemia, appropriate transition of care from pediatric to adult hypertension, role of renal denervation, post-COVID and kidney injury, onconephrology, air pollution, diffusion kurtosis imaging, and dyslipidemia. While chronic kidney disease is by its very nature an entity that inevitably progresses with time, much can be done to reduce the rate of its progression and, by extension, improve both the patient quality of life and the efficiency of healthcare system resource utilization. [ABSTRACT FROM AUTHOR]

Cilj je rada pružiti spoznaje za uspješno usporivanje progresije kronične bubrežne bolesti (KBB) vodeći se najnovijim dokazima i preporukama. Medline i Web of Science baze podataka pretražene su uporabom kombinacije ključnih riječi „kronična bubrežna bolest”, „progresija” i „prevencija”. Relevantni istraživački radovi te trenutačne smjernice nacionalnih i međunarodnih društava analizirani su kako bi se ekstrapolirale preporuke i prilagodbe prakse optimalne za usporivanje progresije KBB-a. Neovisno o etiologiji i tipu KBB-a, postoji mogućnost usporivanja napredovanja bolesti. U ovome je radu predočeno 12 mogućih intervencija za usporivanje KBB-a, i to: dijetne preporuke, liječenje anemije, novi antagonisti mineralokortikoidnih receptora, inhibitori kotransportera natrij glukoze-2, liječenje hiperuricemije, adekvatna tranzicijska skrb hipertenzije od pedijatrijske prema adultnoj dobi, renalna denervacija, utjecaj post-COVID-a i bubrežnog oštećenja, važnost onkonefrologije, utjecaj zagađenja zraka, nove metode procjene bubrežnog oštećenja i liječenje dislipidemije. Iako je KBB po svojoj prirodi pojava s neizbježnom progresijom tijekom vremena, mnogo se može učiniti da bi se smanjila stopa progresije te na taj način poboljšali kvalitetu života bolesnika i učinkovitost korištenja resursima zdravstvenog sustava. [ABSTRACT FROM AUTHOR]