原发性高血压患者血清 miR-192 表达水平与左室肥厚的关系.

Objective　 To investigate the correlation between the expression of miR-192 in serum and left ventricular hypertrophy in patients with essential hypertension. Methods　 The clinical data of 187 patients with essential hypertension treated from June 2018 to December 2019 were selected. All patients were accepted echocardiography to obtain the indexes of LVPWd, IVST, LVEDD, LVESD, LVEDV, LVESV, LAD, LVEF and LVMI. And according to the results of echocardiography, the patients were divided into the hypertrophic group and control group. The expression of miR-192 in serum was detected by real-time fluorescence quantitative PCR. The levels of TGF-β1, type I procollagen carboxy terminal peptide ( PⅠCP) and type III procollagen amino terminal peptide (PⅢNP) were detected by using ELISA. Results　 According to the results of echocardiography, 76 cases of patients had left ventricular hypertrophy (hypertrophy group), and 111 cases had no left ventricular hypertrophy ( control group). Compared with the control group, LVPWT, IVST, LVEDD, LVESD, LVEDV, LVESV, LAD, LVMI, and hs-CRP in the hypertrophic group were all increased (P < 0.05), the serum levels of miR-192, TGF-β1, PⅢNP and PⅠCP in the hypertrophic group were increased (P < 0.05). Pearson correlation analysis showed that the serum level of miR-192 in patients with essential hypertension was positively correlated with the LVPWT, IVST, LVEDD, LVESD, LVEDV, LVESV, LAD, LVMI, TGF-β1, PⅠCP and PⅢNP (P < 0.05). The results of multiple linear regression analysis showed that the LVPWT, IVST, LVEDD, LVESV, TGFβ1, PⅠCP, and PⅢNP were related factors that affected serum level of miR-192 in patients with essential hypertension ( P < 0.05) . Conclusion　 The serum level of miR-192 is elevated in patients with essential hypertension and left ventricular hypertrophy, and is related to the degree of left ventricular hypertrophy and myocardial fibrosis. [ABSTRACT FROM AUTHOR]

目的　 探讨原发性高血压患者血清中 miR-192 表达与左心室肥厚的相关性。方法　 收集 2018 年 6 月至 2019 年 12 月期间治疗的 187 例原发性高血压患者临床资料, 行超声心动图检查获得 LVPWd、IVST、 LVEDD、LVESD、LVEDV、LVESV、LAD、LVEF 和 LVMI 等指标, 并根据超声心动图检查结果将患者分为肥 厚组和对照组。实时荧光定量 PCR 检测血清中 miR-192 表达, ELISA 法测定 TGF-β1、Ⅰ型前胶原羧基末端 肽 (PⅠCP)和Ⅲ型前胶原氨基端肽 (PⅢNP)水平。结果　 经超声心动图检查, 187 例原发性高血压患者中, 76 例出现左心室肥厚 (肥厚组), 111 例未发现左心室肥厚 (对照组)；肥厚组患者 LVPWT、IVST、LVEDD、LVESD、 LVEDV、LVESV、LAD、LVMI 和 hs-CRP 均较对照组升高 (P < 0.05)；肥厚组患者血清中 miR-192、TGF-β1、 PⅢNP 和 PⅠCP 水平较对照组升高 (P < 0.05)；Pearson 相关分析结果显示, 原发性高血压患者血清中 miR-192 水平与 LVPWT、IVST、LVEDD、LVESD、LVEDV、LVESV、LAD、LVMI、TGF-β1、PⅠCP 和 PⅢNP 呈正相 关 (P < 0.05)；多元线性回归分析结果显示, LVPWT、IVST、LVEDD、LVESV、TGF-β1、PⅠCP 和 PⅢNP 是 影响原发性高血压患者血清中 miR-192 水平的相关因素 (P < 0.05)。结论　 血清 miR-192 水平在原发性高血压 左心室肥厚患者中升高, 且与左心室肥厚程度及心肌纤维化有关。 [ABSTRACT FROM AUTHOR]