Canonical T cell receptor docking on peptide–MHC is essential for T cell signaling.
In: Science, Jg. 372 (2021-06-04), Heft 6546, S. 1056-1056
academicJournal
Zugriff:
The article discusses a study which showed that canonical T cell receptor (TCR) docking on peptide-major histocompatibility complex (pMHC) is essential for T cell signaling. Topics covered include the prevalence of reversed-polarity TCR-pMHC recognition within a naive, viral epitope-specific T cell repertoire, the inability of reversed-polarity TCRs to participate in the immune response and what drives the highly conserved docking polarity.
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Canonical T cell receptor docking on peptide–MHC is essential for T cell signaling.
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Autor/in / Beteiligte Person: | Zareie, Pirooz ; Szeto, Christopher ; Farenc, Carine ; Gunasinghe, Sachith D. ; Kolawole, Elizabeth M. ; Nguyen, Angela ; Blyth, Chantelle ; Sng, Xavier Y. X. ; Li, Jasmine ; Jones, Claerwen M. ; Fulcher, Alex J. ; Jacobs, Jesica R. ; Wei, Qianru ; Wojciech, Lukasz ; Petersen, Jan ; Gascoigne, Nicholas R.J. ; Evavold, Brian D. ; Gaus, Katharina ; Gras, Stephanie ; Rossjohn, Jamie |
Zeitschrift: | Science, Jg. 372 (2021-06-04), Heft 6546, S. 1056-1056 |
Veröffentlichung: | 2021 |
Medientyp: | academicJournal |
ISSN: | 0036-8075 (print) |
DOI: | 10.1126/science.abe9124 |
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