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Genome-wide functional analyses of plant coiled–coil NLR-type pathogen receptors reveal essential roles of their N-terminal domain in oligomerization, networking, and immunity.
In: PLoS Biology, Jg. 16 (2018-12-12), Heft 12, S. 1-28
Online
academicJournal
Zugriff:
The ability to induce a defense response after pathogen attack is a critical feature of the immune system of any organism. Nucleotide-binding leucine-rich repeat receptors (NLRs) are key players in this process and perceive the occurrence of nonself-activities or foreign molecules. In plants, coevolution with a variety of pests and pathogens has resulted in repertoires of several hundred diverse NLRs in single individuals and many more in populations as a whole. However, the mechanism by which defense signaling is triggered by these NLRs in plants is poorly understood. Here, we show that upon pathogen perception, NLRs use their N-terminal domains to transactivate other receptors. Their N-terminal domains homo- and heterodimerize, suggesting that plant NLRs oligomerize upon activation, similar to the vertebrate NLRs; however, consistent with their large number in plants, the complexes are highly heterometric. Also, in contrast to metazoan NLRs, the N-terminus, rather than their centrally located nucleotide-binding (NB) domain, can mediate initial partner selection. The highly redundant network of NLR interactions in plants is proposed to provide resilience to perturbation by pathogens. [ABSTRACT FROM AUTHOR]
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Genome-wide functional analyses of plant coiled–coil NLR-type pathogen receptors reveal essential roles of their N-terminal domain in oligomerization, networking, and immunity.
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Autor/in / Beteiligte Person: | Wróblewski, Tadeusz ; Spiridon, Laurentiu ; Martin, Eliza Cristina ; Petrescu, Andrei-Jose ; Cavanaugh, Keri ; Jose-Truco, Maria ; Xu, Huaqin ; Gozdowski, Dariusz ; Pawłowski, Krzysztof ; Michelmore, Richard W. ; Takken, Frank L.W. |
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Zeitschrift: | PLoS Biology, Jg. 16 (2018-12-12), Heft 12, S. 1-28 |
Veröffentlichung: | 2018 |
Medientyp: | academicJournal |
ISSN: | 1544-9173 (print) |
DOI: | 10.1371/journal.pbio.2005821 |
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