СРАВНИТЕЛЬНАЯ ОЦЕНКА НЕКОТОРЫХ МАРКЕРОВ СИСТЕМНОГО ВОСПАЛЕНИЯ У БОЛЬНЫХ ЭСССЕНЦИАЛЬНОЙ ГИПЕРТЕНЗИЕЙ С МЕТАБОЛИЧЕСКИМ СИНДРОМОМ И В УСЛОВИЯХ КОМОРБИДНОСТИ

In patients with essential hypertension (EH) aged 44 - 57years (33 men, 21 women) with metabolic syndrome (n=23) and comorbid peptic ulcer (n=31) there was conducted study o f proinflammatory tumor necrosis factor a in the blood serum, end product o f lipid peroxidation o f malonic dialdehyde, total content o f nitroxide metabolites and ristomycininduced platelet aggregation. It is shown that in patients with comorbid pathology, there was a high proinflummutory activity o f blood serum, significantly intensified process o f lipid peroxidation, elevated content o f tissue component o f primary hemostasis and decreased total content o f nitroxide metabolites, preserved during the period o f clinical laboratory remission. The emphasis on the need to monitor such violations for correction o f treatment and development o f preventive measures was made. [ABSTRACT FROM AUTHOR]