Positive association between ALDH2 rs671 polymorphism and essential hypertension: A case-control study and meta-analysis.
In: PLoS ONE, Jg. 12 (2017-05-04), Heft 5, S. 1-16
Online
academicJournal
Zugriff:
Background and objective: Several studies have been conducted to examine the association between aldehyde dehydrogenase 2 family (ALDH2) rs671 polymorphism and essential hypertension (EH). However, the results remain inconsistent. This study aimed to clarify the association between ALDH2 rs671 polymorphism and EH susceptibility. Methods: One thousand and ninety-four cases and 1236 controls who were ethnic Han Chinese were collected for this population-based case-control study. A meta-analysis was performed to calculate the pooled odds ratio and 95% confidence interval, using allele contrast, dominant, recessive, and co-dominant models using fixed or random-effect models. Results: Significant differences were observed between EH cases and controls at the level of both genotype (χ2 = 6.656, P<0.05) and alleles (χ2 = 6.314, P<0.05). An additional meta-analysis using 4204 cases and 5435 controls established that rs671 was significantly associated with EH (P<0.00001). Conclusion: The results of our case-control study and meta-analysis showed that there is a significant association between ALDH2 rs671 polymorphism and EH susceptibility. In addition, the results of the breakdown analysis by gender suggest a male-specific association between the ALDH2 rs671 polymorphism and EH. [ABSTRACT FROM AUTHOR]
Titel: |
Positive association between ALDH2 rs671 polymorphism and essential hypertension: A case-control study and meta-analysis.
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Autor/in / Beteiligte Person: | Wu, Yinyin ; Ni, Juntao ; Cai, Xiao ; Lian, Fuzhi ; Ma, Haiyan ; Xu, Liangwen ; Yang, Lei |
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Zeitschrift: | PLoS ONE, Jg. 12 (2017-05-04), Heft 5, S. 1-16 |
Veröffentlichung: | 2017 |
Medientyp: | academicJournal |
ISSN: | 1932-6203 (print) |
DOI: | 10.1371/journal.pone.0177023 |
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