Pharmacological and Toxicological Studies of Essential Oil of subsp. Lavandula stoechas luisieri.
In: Planta Medica, Jg. 82 (2016-09-15), Heft 14, S. 1266-1273
serialPeriodical
Zugriff:
The present study was carried out to evaluate the chemical and pharmacological properties of the essential oil of Lavandula stoechas subsp. luisieri, which is a spontaneous shrub widespread in Alentejo (Portugal). Oxygenated monoterpenes, such as 1,8-cineole, lavandulol, and necrodane derivatives, are the main components of essential oil. It revealed important antioxidant activity with a high ability to inhibit lipid peroxidation and showed an outstanding effect against a wide spectrum of microorganisms, such as gram-positive and gram-negative bacteria and pathogenic yeasts. The analgesic effect studied in rats was dose dependent, reaching a maximum of 67% at 60 min with the dose of 200 mg/kg and the anti-inflammatory activity with this dose caused an inhibition in carrageenan-induced rat paw oedema (83%) that is higher than dexamethasone 1mg/Kg (69%). Besides, animals exhibited normal behaviour after essential oil administration, revealing low toxicity. The essential oil of L. luisieri from Alentejo presents important pharmacological properties and low toxicity, and is a promised candidate to be used as a food supplement or in pharmaceutical applications. [ABSTRACT FROM AUTHOR]
Titel: |
Pharmacological and Toxicological Studies of Essential Oil of subsp. Lavandula stoechas luisieri.
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Autor/in / Beteiligte Person: | Arantes, Sílvia ; Candeias, Fátima ; Lopes, Orlando ; Lima, Mónica ; Pereira, Marízia ; Tinoco, Teresa ; Cruz-Morais, J. ; Rosário Martins, M. |
Zeitschrift: | Planta Medica, Jg. 82 (2016-09-15), Heft 14, S. 1266-1273 |
Veröffentlichung: | 2016 |
Medientyp: | serialPeriodical |
ISSN: | 0032-0943 (print) |
DOI: | 10.1055/s-0042-104418 |
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