The transcription factor Foxm1 is essential for the quiescence and maintenance of hematopoietic stem cells.
In: Nature Immunology, Jg. 16 (2015-08-01), Heft 8, S. 810-818
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academicJournal
Zugriff:
Foxm1 is known as a typical proliferation-associated transcription factor. Here we found that Foxm1 was essential for maintenance of the quiescence and self-renewal capacity of hematopoietic stem cells (HSCs) in vivo in mice. Reducing expression of FOXM1 also decreased the quiescence of human CD34+ HSCs and progenitor cells, and its downregulation was associated with a subset of myelodysplastic syndrome (MDS). Mechanistically, Foxm1 directly bound to the promoter region of the gene encoding the receptor Nurr1 (Nr4a2; called 'Nurr1' here), inducing transcription, while forced expression of Nurr1 reversed the loss of quiescence observed in Foxm1-deficient cells in vivo. Thus, our studies reveal a previously unrecognized role for Foxm1 as a critical regulator of the quiescence and self-renewal of HSCs mediated at least in part by control of Nurr1 expression. [ABSTRACT FROM AUTHOR]
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The transcription factor Foxm1 is essential for the quiescence and maintenance of hematopoietic stem cells.
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Autor/in / Beteiligte Person: | Hou, Yu ; Li, Wen ; Sheng, Yue ; Li, Liping ; Huang, Yong ; Zhang, Zhonghui ; Zhu, Tongyu ; Peace, David ; Quigley, John G ; Wu, Wenshu ; Zhao, You-yang ; Qian, Zhijian |
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Zeitschrift: | Nature Immunology, Jg. 16 (2015-08-01), Heft 8, S. 810-818 |
Veröffentlichung: | 2015 |
Medientyp: | academicJournal |
ISSN: | 1529-2908 (print) |
DOI: | 10.1038/ni.3204 |
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