The Correlation between Plasmic Brain Natriuretic Peptide and Essential Hypertension (EH) Target-organ Damage.
In: Journal of Kunming Medical University / Kunming Yike Daxue Xuebao, Jg. 36 (2015-05-01), Heft 5, S. 118-122
academicJournal
Zugriff:
Objective To investigate the association between plasmic Brain Natriuretic Peptide (BNP) and essential hypertension (EH) Target-organ Damage. Methods We studied 83 never-treated patients with essential hypertension and 20 normal subjects. Hypertensive patients were divided into two groups. one group was 68 patients with target-organ damage and the other was 15 patients without target-organ damage (pure hypertensive patients) . Then 68 patients with TOD were subdivide into subgroups: with 30 left ventricular hypertrophy (LVH), 10 carotid artery wall thickening, 10 renal damage and 18 stroke. All subjects received examinations on the general situation, blood pressure, fasting plasma glucose and blood lipid levels, liver function, renal function, urinary albumin, a standard 12-lead ECG, 24-hour blood pressure, echocardiography, carotid ultrasonography and cerebral CT or MRI so on. The plasmic BNP levels were measured by Enzyme-linked immunosorbent assay (ELISA). Results (1) The plasma levels of BNP were elevated in the essential hypertension (EH) group than normal subjects (P < 0.05). (2) The plasma BNP levels in essential hypertension with target organ damage in each subgroup were higher than in pure essential hypertension group and normal control group, the differences were statistically significant (P<0.05). And the plasma BNP levels comparison among various subgroups of essential hypertension with target organ damage, there were no statistically significant difference (P > 0.05). (3) In patients with LVH correlation analysis showed that: The plasma level of BNP had positive correlation with left ventricular mass index (LVMI) (r=0.693, P<0.01), had negative correlation with LVEF (r=-0.768, P<0.01). Conclusions BNP is correlated to the occurrences and developments of essential hypertension and target-organ damage, may become a no-traumatic laboratory indicator in the process of essential hypertension diagnosis and treatment. It has a positive meaning in the disease of changes and prognosis assessment to guide clinical treatment through measuring BNP levels in patients with hypertension and target-organ damage. [ABSTRACT FROM AUTHOR]
Titel: |
The Correlation between Plasmic Brain Natriuretic Peptide and Essential Hypertension (EH) Target-organ Damage.
|
---|---|
Autor/in / Beteiligte Person: | Ping, YANG ; Xiao-hua, DONG ; Qing-yuan, DAI ; Qi-xian, WANG |
Zeitschrift: | Journal of Kunming Medical University / Kunming Yike Daxue Xuebao, Jg. 36 (2015-05-01), Heft 5, S. 118-122 |
Veröffentlichung: | 2015 |
Medientyp: | academicJournal |
ISSN: | 2095-610X (print) |
Sonstiges: |
|