Endogenous Hydrogen Sulfide Production Is Essential for Dietary Restriction Benefits.
In: Cell, Jg. 160 (2015-01-15), Heft 1/2, S. 132-144
academicJournal
Zugriff:
Summary Dietary restriction (DR) without malnutrition encompasses numerous regimens with overlapping benefits including longevity and stress resistance, but unifying nutritional and molecular mechanisms remain elusive. In a mouse model of DR-mediated stress resistance, we found that sulfur amino acid (SAA) restriction increased expression of the transsulfuration pathway (TSP) enzyme cystathionine γ-lyase (CGL), resulting in increased hydrogen sulfide (H 2 S) production and protection from hepatic ischemia reperfusion injury. SAA supplementation, mTORC1 activation, or chemical/genetic CGL inhibition reduced H 2 S production and blocked DR-mediated stress resistance. In vitro, the mitochondrial protein SQR was required for H 2 S-mediated protection during nutrient/oxygen deprivation. Finally, TSP-dependent H 2 S production was observed in yeast, worm, fruit fly, and rodent models of DR-mediated longevity. Together, these data are consistent with evolutionary conservation of TSP-mediated H 2 S as a mediator of DR benefits with broad implications for clinical translation. PaperFlick [ABSTRACT FROM AUTHOR]
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Endogenous Hydrogen Sulfide Production Is Essential for Dietary Restriction Benefits.
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Autor/in / Beteiligte Person: | Hine, Christopher ; Harputlugil, Eylul ; Zhang, Yue ; Ruckenstuhl, Christoph ; Lee, Byung Cheon ; Brace, Lear ; Longchamp, Alban ; Treviño-Villarreal, Jose H. ; Mejia, Pedro ; Ozaki, C. Keith ; Wang, Rui ; Gladyshev, Vadim N. ; Madeo, Frank ; Mair, William B. ; Mitchell, James R. |
Zeitschrift: | Cell, Jg. 160 (2015-01-15), Heft 1/2, S. 132-144 |
Veröffentlichung: | 2015 |
Medientyp: | academicJournal |
ISSN: | 0092-8674 (print) |
DOI: | 10.1016/j.cell.2014.11.048 |
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